Search results for "Cytotoxic drug"
showing 3 items of 3 documents
Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups
2012
[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. In the first step, the pores of an inorganic MCM-41 support (in the form of nanoparticles) were loaded with [Ru(bipy) 3]Cl 2 complex, and then, in the second step, the pore outlets were functionalized with ester glycol moieties that acted as molecular caps. In the absence of an enzyme, release of the complex from aqueous suspensions of S1 at pH 8.0 is inhibited due to the steric hindrance imposed by the bulky ester glycol moieties. Upon addition of esterase enzyme, del…
Measurements of Tumor Blood Flow Using Intraperitoneal Deuterium and 2H-NMR Spectroscopy
1992
Tumors usually have a sparse, disorganized, and inefficient vascular network that leaves a large fraction of the tumor cells in an oxygen deprived and hostile metabolic microenvironment. Hence tumor blood flow, or more correctly nutritive perfusion, has important interactions with treatment efficacy. For example, hypoxic tumor cells, which occur in tumors with low blood flow, are less susceptible to radiation and are probably responsible for most radiation treatment failures (Adams, 1981). Similarly, cytotoxic drug delivery could be predicted by blood flow measurements, with clear implications regarding the expected success of chemotherapy. Thus, the ability to conveniently measure tumor bl…
Implementation and microbiological stability of dose-banded ganciclovir infusion bags prepared in series by a robotic system.
2018
Objectives The implementation of dose-banding (DB) in centralised, pharmacy-based cytotoxic drug preparation units allows the preparation of standardised doses in series. The aim of this study was to evaluate the feasibility of DB for the prescribing of ganciclovir (GV) infusion solutions and to investigate the microbiological stability of dose-banded, automatically prepared ready-to-administer GV infusion bags by media-fill simulation tests and sterility tests. Methods The frequency of prescription of GV doses was retrospectively analysed before and after implementing the DB scheme. Four dose-ranges or ‘bands’ and the corresponding standard doses (250, 300, 350, 400 mg) were identified. Th…